Cryotherapy
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Introduction 

 Demographics

 Anatomy & Physiology

 Symptoms

 Who Should be Evaluated

 Prostate Examination

 Digital Rectal

 PSA

 Total vs. Free Ratio

How to Evaluate for PCa

 Consultation

 Total vs. Free PSA

 Trans Rectal Ultrasound

 Needle Biopsy

 Biopsy Results

What if the Biopsy is Positive?

Gleason Grade

Stage

 Stage A

 Stage B

 Stage C

 Stage D

Therapy Options

Surgery

 Radical Prostatectomy

 Standard Operation    

 Nerve Sparing Oper.

 Positive Margins

 Recurrence after Surgery

Radiation Therapy

 External Beam Therapy

 Interstitial Radiotherapy

 Brachytherapy or Seeds

 Rapid Interstitial Therapy

 Combined Therapy

 Neoadjuvant Therapy or

         Hormones + Radiation

Combined Therapy

Cryotherapy

Hormone Therapy 

 Hormonal Therapy

 Castration

 LHRH Inhibitors

 Total Androgen Blockade

 Neo Adjuvant Therapy or

    Hormones + Radiation

Observation

Late Stage Prostate Cancer

 Cycling antiandrogens

 Chemotherapy

 Cryotherapy

 Bony Metastases

   External Beam Radiation

   Strontium 89

   Bisphosphonates

   Immunotherapy

   Monoclonal Antibodies

   Alternate Medicine

Alternate Medicine

 PC-Spes

 

PCA WEB MAP

 

Stephan L. Werner, M.D., F.A.C.S.

Cryotherapy or freeze therapy is a newer  modality that is being used in some centers to treat initial or recurrent prostate cancer.    Long term results are not yet available, but this new treatment may prove promising.  It one of the few potentially curative treatments that can be given for local prostate cancer recurrence after radiation therapy or seeds.  It may be offered as an alternative to Brachytherapy, (seeds), in patients who have urinary obstructive symptoms, as it helps to open the urinary channel over time.

Cryotherapy is frequently done as an outpatient procedure either at a surgicenter or a hospital. (Medicare at this time requires a hospital admission).  Under regional or general anesthesia   multiple small probes are placed under sonographic guidance, through the perineum, (area between rectum and scrotum), into the prostate. By circulating argon gas through the probes, the prostate and some surrounding tissues are converted into an ice ball.   As the ice ball is repeatedly formed and thawed , the cells are killed, and the area shrinks and is eventually replaced by scar tissue.  A catheter is left in place for a period of time, and the patient goes home the same day.  Pain is minimal, but it takes a period of time for the killed tissue to pass and allow for normal voiding. Some patients require catheterization for several weeks to months or occasionally trans urethral surgery to remove the killed tissue.

Impotence occurs in virtually 100% of patients treated with cryotherapy as the nerves  for erection lie on the surface of the prostate and are frozen as well.  However as the technique develops, "nerve sparing" cryotherapy may become a reality. Incontinence, (loss of urinary control), may occur, but is not common. 

 

 

 Rev:8/02

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Werner - Francis Urology Associates llc - Mid Atlantic Urology Associates llc

Greenbelt - Bowie - Laurel     Maryland

(301) 441-8900               Fax (301) 982 0453

7500 Hanover Parkway   Suite 206    Greenbelt, MD   20770

e-mail: wfurology@gmail.com

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Rev:03/08